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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Aminopterin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Aminopterin
NSC_Code
  • 739
UMLS_CUI
  • C0002583
CAS_Registry
  • 54-62-6
FDA_UNII_Code
  • JYB41CTM2Q
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called antimetabolites.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39141
PDQ_Closed_Trial_Search_ID
  • 39141
Chemical_Formula
  • C19H20N8O5
Legacy_Concept_Name
  • Aminopterin
CHEBI_ID
  • CHEBI:22526
FULL_SYN
  • APGASYDTPNSC0000739
  • AminopterinSYDTPNSC0000739
  • 4-Amino-PGASYNCI
  • AminopterinPTNCI
  • 4-Aminopteroylglutamic acidSYDTPNSC0000739
  • aminopterinPTNCI-GLOSSCDR0000045171
  • Aminopteroylglutamic AcidSYNCI
  • AminopterinPTDCP02633
  • APGAABNCI
  • 4-Aminopteroylglutamic AcidSYNCI
  • 4-Aminofolic AcidSYNCI
  • 4-Aminofolic acidSYDTPNSC0000739
  • AMINOPTERINPTFDAJYB41CTM2Q
DEFINITION
  • A synthetic derivative of pterins with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)NCI
code
  • C235
sameAs
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
is Has_Free_Acid_Or_Base_Form of
is sameAs of
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