About: Sodium Butyrate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sodium Butyrate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Lipid
  • Pharmacologic Substance
Preferred_Name
  • Sodium Butyrate
NSC_Code
  • 174280
UMLS_CUI
  • C0142812
CAS_Registry
  • 156-54-7
FDA_UNII_Code
  • 8RAS91C36W
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39601
PDQ_Closed_Trial_Search_ID
  • 39601
Chemical_Formula
  • C4H7O2.Na
Legacy_Concept_Name
  • Sodium_Butyrate
CHEBI_ID
  • CHEBI:64103
FULL_SYN
  • Butyric Acid, Sodium SaltPTDCP01098
  • butyric acid, sodium saltSYNCI
  • SODIUM BUTYRATEPTFDA8RAS91C36W
  • Sodium ButyratePTNCI
  • sodium butanoateSYNCI
  • Sodium butyrateSYDTPNSC0174280
  • Butyrate sodiumSYDTPNSC0174280
  • Sodium butanoateSYDTPNSC0174280
  • ButyrateSYNCI
DEFINITION
  • The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling.NCI
code
  • C2337
Faceted Search & Find service v1.16.121 as of Mar 31 2025


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 13 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software