About: Anti-CD33 Immunotoxin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Anti-CD33 Immunotoxin
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Anti-CD33 Immunotoxin
UMLS_CUI
  • C1510923
Legacy_Concept_Name
  • Anti-CD33_Immunotoxin
FULL_SYN
  • Anti-CD33 ImmunotoxinPTNCI
DEFINITION
  • An immunoconjugate of the humanized monoclonal antibody hP67.6 chemically linked to a bacterial toxin, N-acetyl-gamma calicheamicin, by 4-acetylphenylacetic acid, with antileukemic property. The monoclonal antibody portion specifically binds to CD33 antigen, a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells as well as over-expressed on myelogenous leukemia cells. Upon internalization, calicheamicin, an enediyne class antibiotics, is released from the conjugate by hydrolysis, and binds in a sequence specific manner to the minor groove of DNA. Thereby leads to breakage of double-stranded DNA and consequently resulting in cell death.NCI
code
  • C2333
is rdfs:subClassOf of
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