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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Triapine
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Triapine
NSC_Code
  • 663249
UMLS_CUI
  • C0210403
CAS_Registry
  • 236392-56-6
In_Clinical_Trial_For
  • Advanced Prostate Cancer; Hematologic Malignancy; Non-Small Cell Lung Cancer; Pancreatic Cancer.
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is a type of ribonucleotide reductase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37830
PDQ_Closed_Trial_Search_ID
  • 37830
Legacy_Concept_Name
  • Triapine
FULL_SYN
  • 3-APPTNCI-GLOSSCDR0000044881
  • 3-aminopyridine-2-carboxaldehyde thiosemicarbazonePTNCI-GLOSSCDR0000044850
  • 3-APABNCI
  • 3-ApctABNCI
  • OCX-191CNNCI
  • TriapinePTNCI-GLOSSCDR0000367459
  • TriapinePTNCI
  • 3-Aminopyridine-2-carboxaldehyde ThiosemicarbazoneSNNCI
DEFINITION
  • A synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro. (NCI04)NCI
code
  • C2242
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
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