About: Prostatic Intraepithelial Neoplasia of the Mouse Prostate Gland

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About: Prostatic Intraepithelial Neoplasia of the Mouse Prostate Gland Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Prostatic Intraepithelial Neoplasia of the Mouse Prostate Gland
rdfs:subClassOf	Mouse Intraepithelial Neoplasia High Risk Proliferative Disease of the Mouse Prostate Gland of Unknown or Premalignant Potential
Semantic_Type	Neoplastic Process
Display_Name	Prostatic Intraepithelial Neoplasia of the Prostate Gland
Preferred_Name	Prostatic Intraepithelial Neoplasia of the Mouse Prostate Gland
UMLS_CUI	C1522511
ALT_DEFINITION	Conceptually, distinguished from epithelial hyperplasia with atypia by unequivocally documented association with invasive carcinoma, such that the terms PIN/HGPIN have similar meaning/implications as in human. Thus far, such invasion has been observed primarily in SV40 early region/large T antigen containing transgenes (and possibly the BK5-IGF1 mouse). In these models, the in situ lesions CAN be distinguished morphologically from mice showing epithelial proliferation with atypia. T antigen models show much more pronounced nuclear atypia, including greater nuclear enlargement and pleomorphism, coarser chromatin, irregular nuclear contours, and higher mitotic and apoptotic rates.MMHCC Mouse PIN (mPIN) is defined histologically as proliferation of atypical epithelial cells within pre-existing glands and ducts and is still confined by the basement membrane.MMHCC Epithelial proliferation with nuclear atypia, without invasion. Proliferation typically manifest as nuclear stratification. Atypia manifest as progressively severe nuclear enlargement, chromatin abnormalities, and enlarged nucleoli.MMHCC
Legacy_Concept_Name	Prostatic_Intraepithelial_Neoplasia_of_the_Mouse_Prostate_Gland
FULL_SYN	Prostatic intraepithelial neoplasia (PIN)SYCTRM Prostatic Intraepithelial Neoplasia of the Mouse Prostate GlandPTNCI PINSYCTRM Prostatic Intraepithelial Neoplasia of the Prostate GlandDNCTRM
code	C21728
is rdfs:subClassOf of	Low Grade Mouse Prostatic Intraepithelial Neoplasia High Grade Mouse Prostatic Intraepithelial Neoplasia

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