About: Prolactin 16-kD Fragment     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Prolactin 16-kD Fragment
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Prolactin 16-kD Fragment
UMLS_CUI
  • C1514483
Legacy_Concept_Name
  • Prolactin_16-kD_Fragment
FULL_SYN
  • Prolactin 16-kD FragmentPTNCI
  • 16K PRLABNCI
DEFINITION
  • A 16 kD N-terminal fragment of prolactin formed endogenously by cleavage of intact prolactin. Possessing anti-angiogenic properties, prolactin 16-kD fragment inhibits the pro-angiogenic effects of basal fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) on endothelial cell proliferation, migration, and capillary organization. This agent also induces caspase-mediated endothelial cell apoptosis and upregulates the expression of plasminogen activator inhibitor-1 (PAI-1); PAI-1 inhibits the activity of urokinase, an enzyme essential to angiogenesis. (NCI04)NCI
code
  • C2047
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