About: TNF Receptor Family Protein

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	TNF Receptor Family Protein
rdfs:subClassOf	Receptors, Cytokine
Semantic_Type	Amino Acid, Peptide, or Protein Receptor
Preferred_Name	TNF Receptor Family Protein
UMLS_CUI	C0077503
ALT_DEFINITION	Cell surface receptors that bind tumor necrosis factor and trigger changes which influence the behavior of cells. The two recognized tumor necrosis factor receptors are designated alpha and beta receptors. Both receptors bind both alpha and beta tumor necrosis factors with high affinity, and both are members of the nerve growth factor receptor family.MSH2001
Legacy_Concept_Name	TNF_Receptor_Family_Protein
FULL_SYN	Tumor Necrosis Factor Receptor SuperfamilySYNCI TNF ReceptorSYNCI TNF Receptor SuperfamilySYNCI TNFRSF ProteinSYNCI TNFRSYNCI Tumor Necrosis Factor Receptor FamilySYNCI TNF Receptor Family ProteinPTNCI Tumor Necrosis Factor ReceptorSYNCI
DEFINITION	Members of the tumor necrosis factor receptor (TNFR) family play a key role in regulating the immune response to infection. They are cell-surface proteins that interact with a corresponding TNF-related ligand family. The receptors share homology in the extracellular domain, which contains 3 to 6 cysteine-rich pseudorepeats, but are generally not related in their cytoplasmic regions. However, the intracellular domains (ICDs) of TNFR family members TNFR1 and FAS/APO1/CD95, which can activate apoptotic cell death, do have a region of homology in an oligomerization interface known as the death domain. (from OMIM 603366)NCI
code	C19285
sameAs	Receptors, Tumor Necrosis Factor
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0027329
is rdf:first of	nodeID://b739936 nodeID://b739937 nodeID://b739938 nodeID://b739939 nodeID://b739940 nodeID://b739941 nodeID://b739942 nodeID://b739943 nodeID://b739944 nodeID://b739945 nodeID://b739946 nodeID://b739947 nodeID://b739948 nodeID://b739949
is rdfs:subClassOf of	TNFRSF8 Gene Product Tumor Necrosis Factor Receptor Superfamily Member 18 Tumor Necrosis Factor Receptor Superfamily Member 21 Receptor Activator of Nuclear Factor-kappa B CD27 Antigen
is sameAs of	Receptors, Tumor Necrosis Factor

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