About: ILX23-7553     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • ILX23-7553
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • ILX23-7553
UMLS_CUI
  • C0966846
ALT_DEFINITION
  • A substance that is being studied as an anticancer drug.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37861
PDQ_Closed_Trial_Search_ID
  • 37861
Legacy_Concept_Name
  • ILX23-7553
FULL_SYN
  • 1,25-dihydroxy-16-ene-23-yne-cholecalciferolSNNCI
  • Ro23-7553CNNCI
  • ILX23-7553PTNCI-GLOSSCDR0000044892
  • ILX23-7553CNNCI
  • ILX23-7553PTNCI
DEFINITION
  • A vitamin D3 analogue with potential antineoplastic activity. ILX23-7553 binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, ILX23-7553 may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated.NCI
code
  • C1883
http://linked.open...y/mesh/hasConcept
Faceted Search & Find service v1.16.121 as of Mar 31 2025


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 14 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software