About: Lurtotecan Liposome     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Lurtotecan Liposome
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lurtotecan Liposome
UMLS_CUI
  • C0935959
PDQ_Open_Trial_Search_ID
  • 43473
PDQ_Closed_Trial_Search_ID
  • 43473
Legacy_Concept_Name
  • Lurtotecan_Liposome
FULL_SYN
  • NX211CNNCI
  • OSI-211CNNCI
  • Lurtotecan LiposomePTNCI
  • liposome, lurtotecanSYNCI
  • liposomal lurtotecanSYNCI
DEFINITION
  • A liposome-encapsulated formulation of lurtotecan with antineoplastic activity. Lurtotecan, a semisynthetic analogue of camptothecin, selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex during S phase of the cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-stranded DNA breaks. This ultimately results in an inhibition of DNA replication, inducing double-stranded DNA breakages, obstruction of RNA and protein synthesis and triggering apoptosis. Furthermore, this agent also stimulates degradation of topoisomerase I, likely mediated through ubiquitin-proteasomal pathway. Liposomal delivery of lurtotecan improves its penetration and delivery into tumors while lowering systemic side effects.NCI
code
  • C1876
http://linked.open...y/mesh/hasConcept
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