About: Peginterferon Alfa-2b

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About: Peginterferon Alfa-2b Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Peginterferon Alfa-2b
rdfs:subClassOf	Pegylated Interferon Alfa
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Immunologic Factor
Preferred_Name	Peginterferon Alfa-2b
NSC_Code	720033
UMLS_CUI	C0796545
CAS_Registry	215647-85-1
Accepted_Therapeutic_Use_For	chronic hepatitis C; renal cell carcinoma
In_Clinical_Trial_For	Metastatic or unresectable carcinoid tumors; recurrent high-grade gliomas; childhood diffuse pontine glioma; chronic myeloid leukemia; stage IV melanoma and renal cell cancer.
FDA_UNII_Code	G8RGG88B68
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat hepatitis C infections. It is also being studied in the treatment and prevention of cancer. It is a cytokine that is modified in the laboratory. It is a type of biological response modifier.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43407
PDQ_Closed_Trial_Search_ID	43407
Chemical_Formula	C2H4NO2(C2H4O)n
Legacy_Concept_Name	PEG-Interferon_Alfa-2B
CHEBI_ID	CHEBI:63615
FULL_SYN	PEG-Interferon Alfa-2bSYNCI PEG-IntronPTNCI-GLOSSCDR0000410755 PEG-IFN-a 2bABNCI PEGINTERFERON ALFA-2BPTFDAG8RGG88B68 PEG-IFN Alfa-2bSYNCI Polyethylene Glycol IFN-A2bSYNCI Polyethylene Glycol Interferon Alfa-2bSYNCI PEG-interferon alfa-2bPTNCI-GLOSSCDR0000046202 SCH 54031SYNCI-GLOSSCDR0000046746 SylatronBRNCI Peginterferon Alfa-2bPTNCI PEG-IntronFBNCI
DEFINITION	A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2b protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2b, thereby extending the duration of its therapeutic effects, but may also reduce the interferon-mediated stimulation of an immune response. (NCI04)NCI
code	C1845
sameAs	PEGINTERFERON ALFA-2B PEGINTERFERON ALFA-2B
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0374956
is someValuesFrom of	nodeID://b650355 nodeID://b699118 nodeID://b699121
is sameAs of	PEGINTERFERON ALFA-2B PEGINTERFERON ALFA-2B PEGINTERFERON ALFA-2B

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