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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Representational Difference Analysis
rdfs:subClassOf
Semantic_Type
  • Molecular Biology Research Technique
Preferred_Name
  • Representational Difference Analysis
UMLS_CUI
  • C0597707
ALT_DEFINITION
  • PCR-based method for isolating unique sequences; also, used for comparing differences between two complex genomes.CSP2000
Legacy_Concept_Name
  • Representational_Difference_Analysis
FULL_SYN
  • RDAABNCI
  • Representational Difference AnalysisPTNCI
DEFINITION
  • This PCR technique enables researchers to compare the DNA of normal and afflicted tissue to isolate the DNA regions gained or lost in disease carriers. The essence of the technique is to compare two regions of DNA, one with a "target sequence" and one without. The target sequence may be either DNA added to the genome, by a virus or by genetic amplification, or DNA deleted from a normal chromosome, as in many cancers. Pairing DNA fragments from healthy and diseased tissue allows researchers to quickly identify missing or added DNA sequence and thereby pinpoint genetic alterations that may be involved in disease. (from Cold Spring Harbor)NCI
code
  • C18114
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