About: Thrombopoietin Receptor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Thrombopoietin Receptor
equivalentClass
OMIM_Number
  • 159530
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Thrombopoietin Receptor
UMLS_CUI
  • C0218227
Legacy_Concept_Name
  • Thrombopoietin_Receptor
FULL_SYN
  • MPLSYNCI
  • TPORSYNCI
  • CD110SYNCI
  • Thrombopoietin ReceptorPTNCI
  • CD110 AntigenSYNCI
  • c-MPL ProteinSYNCI
Swiss_Prot
  • P40238
DEFINITION
  • Thrombopoietin receptor (635 aa, 71 kD) is a cell division process protein that is encoded by the human MPL gene and has roles in cell proliferation and signal transduction.NCI
DesignNote
  • MPL encodes the Thrombopoietin Receptor, a member of the cytokine receptor superfamily. The mechanism by which TPO activates the TPOR appears similar to that of other hematopoietic cytokines that bind and induce receptor homodimerization. TPO regulates the production of multipotent hematopoietic progenitor cells and platelets. Lymphoid progenitors express IL7R and not MPL, whereas myeloid progenitors express MPL and not IL7R. The receptor for thrombopoietin may also represent a regulatory molecule specific for TPOR-dependent immune responses. TPOR contains two fibronectin type III-like domains and is a type I membrane protein. Two isoforms, MPL-K and MPL-P, are produced by alternative splicing and are co-expressed. (from OMIM 159530, SWISS-PROT P40238, and NCI)
code
  • C17695
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