About: Antineoplaston AS2-1

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About: Antineoplaston AS2-1 Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Antineoplaston AS2-1
rdfs:subClassOf	Antineoplaston Agent
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Antineoplaston AS2-1
NSC_Code	620261
UMLS_CUI	C0294295
CAS_Registry	104624-98-8
In_Clinical_Trial_For	Mesothelioma; multiple myeloma; neuroectodermal tumor; pancreatic cancer; prostate cancer; rhabdoid tumor of the CNS Adrenal gland cancer; astrocytoma; brain tumor; breast cancer; colon cancer; ependymoma; esophageal cancer; glioblastoma multiforme; lung cancer; lymphoma; melanoma
PDQ_Open_Trial_Search_ID	41985
PDQ_Closed_Trial_Search_ID	41985
Legacy_Concept_Name	Antineoplaston_AS2-1
FULL_SYN	Antineoplaston AS2-1SYDTPNSC0620261 Antineoplaston AS2-1PTNCI
DEFINITION	A 4:1 mixture of phenylacetate and phenylacetylgluatmine, degradation products of the antineoplaston agent A10. Antineoplaston AS2-1 inhibits the incorporation of L-glutamine into tumor-cell proteins, leading to cell cycle arrest in the G1 phase and inhibition of mitosis. This agent may also inhibit RAS oncogene expression and activate tumor suppressor gene p53, resulting in cell differentiation and apoptosis. (NCI04)NCI
code	C1613
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0243025
is someValuesFrom of	nodeID://b646356

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