About: Glufosfamide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Glufosfamide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Organophosphorus Compound
Preferred_Name
  • Glufosfamide
UMLS_CUI
  • C0912322
CAS_Registry
  • 132682-98-5
FDA_UNII_Code
  • 1W5N8SZD9A
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42676
PDQ_Closed_Trial_Search_ID
  • 42676
Chemical_Formula
  • C10H21Cl2N2O7P
Legacy_Concept_Name
  • Glufosfamide
FULL_SYN
  • GlufosfamidePTNCI
  • Beta-D-Glucosyl-Ifosfamide MustardSYNCI
  • glufosfamidePTNCI-GLOSSCDR0000045540
  • D-19575CNNCI
  • glc-IPMABNCI
  • GLUFOSFAMIDEPTFDA1W5N8SZD9A
DEFINITION
  • A compound consisting of the mustard agent ifosforamide conjugated to glucose, with potential alkylating activity. Glufosfamide is cleaved by glucosidases in tumor cells and forms ifosforamide. In turn, ifosforamide alkylates and forms DNA crosslinks, thereby inhibiting DNA replication and subsequent cell growth. The glucose moiety may enhance this agent's uptake by tumor cells.NCI
code
  • C1612
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