About: Immunoglobulin Domain     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Immunoglobulin Domain
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • Immunoglobulin Domain
UMLS_CUI
  • C1512665
Legacy_Concept_Name
  • Immunoglobulin_Domain
FULL_SYN
  • Immunoglobulin-Like DomainSYNCI
  • Immunoglobulin DomainPTNCI
DEFINITION
  • The major histocompatibility complex (MHC) molecules are made of 2 chains, alpha and beta. In class I, the alpha chain is composed of 3 extracellular domains, a transmembrane region and a cytoplasmic tail while the beta chain is of a single extracellular domain. In class II, both the alpha and the beta chains are composed of 2 extracellular domains, a transmembrane region and a cytoplasmic tail. The immunoglobulin (Ig) constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately one hundred amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions, e.g., antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. (InterPro IPR007110)NCI
code
  • C13806
is rdfs:subClassOf of
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