About: O-Chloroacetylcarbamoylfumagillol     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • O-Chloroacetylcarbamoylfumagillol
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • O-Chloroacetylcarbamoylfumagillol
NSC_Code
  • 642492
UMLS_CUI
  • C0081489
CAS_Registry
  • 129298-91-5
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41725
PDQ_Closed_Trial_Search_ID
  • 41725
Legacy_Concept_Name
  • TNP-470
FULL_SYN
  • O-ChloroacetylcarbamoylfumagillolPTNCI
  • (3R,4S,5S,6R)-5-Methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) CarbamateSNNCI
  • TNP-470SYDTPNSC0642492
  • AGM-1470SYDTPNSC0642492
  • 5-Methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl)carbamateSNNCI
  • TNP-470PTNCI-GLOSSCDR0000045394
  • [3R-[3alpha,4alpha(2R*,3R*),5beta,6beta]]-5-Methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl (chloroacetyl)carbamatePTDCP09176
  • TNP-470CNNCI
  • AGM-1470CNNCI
DEFINITION
  • A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI04)NCI
code
  • C1298
http://linked.open...y/mesh/hasConcept
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