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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Oltipraz
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Oltipraz
NSC_Code
  • 347901
UMLS_CUI
  • C0069456
CAS_Registry
  • 64224-21-1
FDA_UNII_Code
  • 6N510JUL1Y
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used in cancer prevention.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41866
PDQ_Closed_Trial_Search_ID
  • 41866
Chemical_Formula
  • C8H6N2S3
Legacy_Concept_Name
  • Oltipraz
FULL_SYN
  • 5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thioneSNNCI
  • 3H-1,2-Dithiole-3-thione,4-methyl-5-pyrazinylSNNCI
  • 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thioneSNNCI
  • 5-[2-Pyrazinyl]-4-methyl-1,2-3-thioneSNNCI
  • 4-Methyl-5-(pyrazinyl)-3H-1,2-dithiole-3-thioneSNNCI
  • OLTIPRAZPTFDA6N510JUL1Y
  • OltiprazSYDTPNSC0347901
  • OltiprazPTNCI
  • oltiprazPTNCI-GLOSSCDR0000045406
  • RP-35,972ABNCI
  • 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-SYDTPNSC0347901
  • OltiprazPTDCP00071
DEFINITION
  • A synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.NCI
code
  • C1177
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