About: Smoothened Receptor Antagonist LY294068     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Smoothened Receptor Antagonist LY294068
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Smoothened Receptor Antagonist LY294068
NCI_META_CUI
  • CL433735
PDQ_Open_Trial_Search_ID
  • 688313
PDQ_Closed_Trial_Search_ID
  • 688313
FULL_SYN
  • 4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamideSNNCI
  • Smoothened Receptor Antagonist LY294068PTNCI
  • LY2940680CNNCI
DEFINITION
  • An orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. Smo inhibitor LY2940680 inhibits signaling that is mediated by the Hh pathway protein Smo, which may result in a suppression of the Hh signaling pathway and may lead to the inhibition of the proliferation of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.NCI
code
  • C103826
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