About: Caracemide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Caracemide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Caracemide
NSC_Code
  • 253272
UMLS_CUI
  • C0054633
CAS_Registry
  • 81424-67-1
FDA_UNII_Code
  • H74F6J185A
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39751
PDQ_Closed_Trial_Search_ID
  • 39751
Chemical_Formula
  • C6H11N3O4
Legacy_Concept_Name
  • Caracemide
FULL_SYN
  • N-Acetyl-N-(methylcarbamoyloxy)-N'-methylureaSNNCI
  • Acetamide, N-[(Methylamino)carbonyl]-N-[[(methylamino)carbonyl]oxy]-(9CI)SNNCI
  • Acetamide, N-[(methylamino)carbonyl]-N-[[(methylamino)carbonyl]oxy]- (9CI)SYDTPNSC0253272
  • CARACEMIDEPTFDAH74F6J185A
  • CaracemidePTNCI
DEFINITION
  • An agent derived from acetohydroxamic acid with potential antineoplastic activity. Caracemide inhibits ribonuclease reductase, resulting in decreased DNA synthesis and tumor growth; it also inhibits acetylcholinesterase. In vivo, caracemide contributes to the formation of the neurotoxin methyl isocyanate; this effect, along with the agent's acetylcholinesterase activity, may be responsible for the severe central nervous system toxicity observed in clinical trials. (NCI04)NCI
code
  • C1037
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