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AttributesValues
rdf:type
rdfs:label
  • Nanoparticle-encapsulated Doxorubicin Hydrochloride
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Nanoparticle-encapsulated Doxorubicin Hydrochloride
NCI_META_CUI
  • CL437178
PDQ_Open_Trial_Search_ID
  • 738259
PDQ_Closed_Trial_Search_ID
  • 738259
FULL_SYN
  • Nanoparticle-encapsulated Doxorubicin HydrochloridePTNCI
  • BA-003CNNCI
  • LivatagFBNCI
  • Doxorubicin TransdrugFBNCI
DEFINITION
  • A formulation of nanoparticles encapsulating the hydrochloride salt form of the anthracycline antibiotic doxorubicin, with potential antitumor activity. Upon intravenous administration, doxorubicin intercalates DNA, interferes with the activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Delivery of doxorubicin in nanoparticles may improve drug penetration into tumors and may circumvent the tumor cells multidrug resistance mechanisms and may therefore be effective in chemoresistant tumor cells.NCI
code
  • C102875
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