About: CYP17 Inhibitor CFG920     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CYP17 Inhibitor CFG920
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CYP17 Inhibitor CFG920
NCI_META_CUI
  • CL437136
PDQ_Open_Trial_Search_ID
  • 737730
PDQ_Closed_Trial_Search_ID
  • 737730
FULL_SYN
  • CFG920CNNCI
  • CYP17 Inhibitor CFG920PTNCI
DEFINITION
  • An orally available inhibitor of the steroid 17-alpha-hydroxylase/C17,20 lyase (CYP17A1 or CYP17), with potential antiandrogen and antineoplastic activities. Upon oral administration, CYP17 inhibitor CFG920 inhibits the enzymatic activity of CYP17A1 in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1, localized to the endoplasmic reticulum, exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones.NCI
code
  • C102855
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