About: Ansamycin Antineoplastic Antibiotic     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ansamycin Antineoplastic Antibiotic
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Ansamycin Antineoplastic Antibiotic
UMLS_CUI
  • C0051936
ALT_DEFINITION
  • An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics.NCI-GLOSS
Legacy_Concept_Name
  • Ansamycin_Antineoplastic_Antibiotic
CHEBI_ID
  • CHEBI:22565
FULL_SYN
  • Ansamycin Antineoplastic AntibioticPTNCI
  • ansamycinPTNCI-GLOSSCDR0000046677
  • Ansamycin AntibioticsSYNCI
  • AnsamycinsSYNCI
DEFINITION
  • An antineoplastic antibiotic of macrocyclic benzoquinone isolated from the bacterial genus Streptomyces. Ansamycin antibiotics bind to and inhibit the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins and the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells.NCI
code
  • C1003
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