About: Analysis of biologically important molecular complexes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz:8890 associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=VS97032
Description	The aim of the project is to build a laboratory focused on the study of functionally important complexes of biomacromolecules, namely those of nucleic acids and proteins, which form so called genome architecture (telomeres, centromeres, A study of the genetic heterochromatin blocks, complexes of nuclear matrix, nucleosomes). Metabolism of genetic material (replication, transcription, recombination) proceeds at these complexes and is, therefore, significantly affected by their properties. information in its nuclear context will determine the basis of education of our postgraduate students. During the next four years, the nucleoprotein complexes will be characterised, which form indispensable functional elements of eukaryotic chromosomes - the telomeres. (en) Cílem projektu je vytvoření laboratoře zaměřené na studium funkčně významných komplexů biomakromolekul, zejm. nukleových kyselin a proteinů, které tvoří tzv. architekturu genomu (telomery, centromery, bloky heterochromatinu, komplexy jaderné matrix, nuklozómy). Metabolismus genetického materiálu (replikace, transkripce, rekombinace) probíhá na těchto komplexech a proto výrazně závisí na jejich vlastnostech. Studium genetické informace v jaderném kontextu bude osou výchovy našich postgraduálních studentůV následujících čtyřech letech budou charakterizovány nukleoproteinové komplexy tvořící nepostradatelné funkční elementy eukaryontních chromozómů - telomery.
Title	Analysis of biologically important molecular complexes (en) Analýza biologicky významných molekulárních komplexů
skos:notation	VS97032
http://linked.open...avai/cep/aktivita	Strengthening of research at the universities
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/VS97032/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/VS97032/celkoveNaklady
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	598605
http://linked.open...ai/cep/hlavniObor	BO - Biofyzika
http://linked.open...hodnoceniProjektu	U - Uspěl podle zadání, tj. byly splněny cíle a jeho předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory
http://linked.open.../cep/klicovaSlova	biomacromolecules; nucleoprotein complexes; chromatin structure; chromosome architecture; telomeres (en)
http://linked.open...ep/partnetrHlavni	Přírodovědecká fakulta
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	45 (xsd:int)
http://linked.open...enychVysledkuVRIV	45 (xsd:int)
http://linked.open...iciPoslednihoRoku	2001
http://linked.open...atUdajeProjZameru	2001
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	CE - Biochemie EB - Genetika a molekulární biologie
http://linked.open...jektu+dodavatelem	Pracoviště se věnuje analýze biolog. významných molekulárních komplexů struktury chromozómů, především jejich nepostradatelných koncových domén telomer. Proveden objev telomerázy (enzymového komplexu syntetizujícího telomery) v rostlinných buňkách. (cs)
http://linked.open...tniCyklusProjektu	ZBBKU
http://linked.open.../cep/klicoveSlovo	chromatin structure chromosome architecture nucleoprotein complexes biomacromolecules
is http://linked.open...vavai/riv/projekt of	Developmental Control of Telomere Lengths and Telomerase Activity in Plants DNA loop domains in a 1.4-Mb region around the human hprt gene mapped by cleavage mediated by nuclear matrix-associated topoisomerase II Dynamics of plant telomeres DNA methylation state of the CpG island at the Pa promoter within the bcr-abl locus followed in CML patients Developmenthal control of telomere lengths and telomerase activity in plants Dynamics of Plant Telomeres. Developmental control of telomeres lengths and telomerase activity in plants. DNA methylation of the CpG island at the Pa promoter within the bcr-abl locus followed in CML patients. Dissection of homologous recombination Detailed mapping of methylcythosine positions at the CpG island surrounding the Pa promoter at the bcr-abl locus in CML patients and in two cell lines, K562 and BV173 Telomeric repeat organization-a comparative in situ study between man and rodent Using detection of telomerase activityand expression in oncology diagnostics Telomeráza - aktivita a diagnostické použití u leukémií a solidních tumorů Telomerase activity, telomere length and telomere structure in the dicot plant silene latifolia Targeted deletions created in yeast vectors by recombinational excision The Health Industry Council Homomeric Interaction Of the Mouse Rad52 Protein PCR-RFLP rapid detection and species identification of fungal pathogens in patients with febrile neutropenia Transition between two forms of heterochromatin at plant subtelomeres Telomerase Activity,Expression and Telomere in situ Analysis in the Course of Treatment of Childhood Leukemias Telomere-binding Proteins from Nuclei of Telomerase-Negative Tissues Inhibit Plant Telomerase (invited lecture) Telomerase activity and expression in the course of treatment of acute childhood leukemias Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias Telomerase Activity and Expression and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias TAS49-a dispersed repetitive sequence isolated from subtelomeric regions of Nicotiana tomentosiformis chromosomes Telomerase activity and expression in the course of treatment of acute childhood leukemias. Plant cells express telomerase activity upon transfer to callus culture, without extensively changing telomere lengths Monitoring de novo of methylation of Pa promoter in the course of CML Telomere dynamics during plant development Telomere dynamics during plant differentiation and dedifferentiation Telomere dynamics during plant development. An in Situ Study of Variant Telomeric Repeats in Human Chromosomes In situ studies of human telomeres Molecular Cytogenetics Investigation of The Telomers in a Case of Philadelphia Positive B-ALL with a Single Telomere Expansion Molecular Dissection of Homologous Recombination Sledování aktivity telomerázy v průběhu léčby dětských leukémií Analysis of the G-overhang structures on plant telomeres: evidence for two distinct telomere architectures Detailed Mapping of Methylcythosine Positions at the CpG Island Surrounding tha Pa Promoter at the bcr-abl Locus in CML Patients in Two Cell Lines, K562 and BV 173 DNA and Chromatin Structure of Telomere-Subtelomere Junctions in Silene latifolia Detailed Mapping of Methylcytosine Positions at the CpG Island Surrounding the Pa Promoter at the bcr-abl Locus in CML Patients and in Two Cell Lines, K562 and BV173. Inhibition of plant telomerase by telomere-binding proteins from nuclei of telomerase-negatative tissues Inhibition of plant telomerase by telomere-binding proteins from nuclei of telo Inhibition of plant telomerase by telomere-binding proteins from nuclei of telomerase-negative tissues. Columnar Packing of Telomeric Nucleosomes The acute nephrotoxicity of selected cytostatics in children with malignancy
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS97032/1997/ico%3A00216224 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS97032/1998/ico%3A00216224 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS97032/1999/orjk%3A14310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS97032/2000/orjk%3A14310 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/VS97032/2001/orjk%3A14310

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