About: Structure and interactions of nucleic acids and polypeptides at metal surfaces

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz:8890 associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=IAA4004002
Description	The interactions of nucleic acid bases, nucleotides, polynucleotides and polypeptides adsorbed at the surfaces of mercury and some metal monocrystals will be studied by the electrochemical impedance spectroscopy, ellipsometry and STM/AFM microscopy. The interactions berween adsorbed bases can result in their two-dimensional (2-D) condensation. The course of 2-D condensation of nucleic acid bases at the mercury and gold surface will be compared and the effect of ribose and deoxyribose will be determined.The experimental results will be compared with the quantum chemical calculations. The aim of the proposed project is to obtain information on the effect of the electric field of the metal-solution interface on the structure of biopolymers and on the interactions of theirs monomeric components. The results can contribute to clear up the molecular mechanism of the interactions of biopolymers with charged membrane surfaces and with chemotherapeutics. (en) Interakce bazí nukleových kyselin, nukleosidů, polynukleotidů a polypeptidů adsorbovaných na povrchu rtuti a monokrystalů některých kovů budou studovány elektrochemickou impedanční spektroskopií, elipsometrií a metodami mikroskopie STM a AFM. Interakce mezi adsorbovanými bazemi mohou vést k jejich dvojrozměrné (2-D) kondenzaci. Bude porovnán průběh 2-D kondenzace bazí nukleových kyselin na povrchu rtuti a na povrchu zlata a bude stanoven vliv ribosy a deoxyribosy na tento průběh. Experimentální výsledky budou porovnány s kvantově chemickými výpočty. Cílem navrhovaného projektu je získat informace o působení elektrického pole fázového rozhraní mezi roztokem a kovovou elektrodou na strukturu biopolymerů a na interakce jejich monomerních složek. Výsledky přispějí k objasnění molekulárního mechanismu interakce biopolymerů s elektricky nabitými povrchy membrán a s chemoterapeutiky.
Title	Structure and interactions of nucleic acids and polypeptides at metal surfaces (en) Struktura a interakce nukleových kyselin a polypeptidů na površích kovů
skos:notation	IAA4004002
http://linked.open...avai/cep/aktivita	Grants of distinctly investigative character focused on the sphere of research pursued at present particularly in the Academy of Sciences of the Czech Republic
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA4004002/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/IAA4004002/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2004-10-27 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	1068880
http://linked.open...ai/cep/hlavniObor	CG - Elektrochemie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cep/klicovaSlova	molecular dynamics; G-DNA; quadruplex; mixed quartet; quanine quartet; electrochemical impedance spectroscopy; nucleoside adsorption; DNA adsorption; polypeptide adsorption; two-dimensional condensation; electrode double layer; voltammetry; (en)
http://linked.open...ep/partnetrHlavni	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	41 (xsd:int)
http://linked.open...enychVysledkuVRIV	41 (xsd:int)
http://linked.open...iciPoslednihoRoku	2003
http://linked.open...atUdajeProjZameru	2003
http://linked.open.../vavai/cep/soutez	SAV0-AB2000
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	CF - Fyzikální chemie a teoretická chemie BO - Biofyzika
http://linked.open...jektu+dodavatelem	Mezimolekulární interakce nukleosidů vedou k jejich 2D kondenzaci na povrchu elektrod. Kinetika kondenzace závisí na pH prostředí a elektrickém poli elektrody. Smíšené kvadruplexy tetranukleotidů vyžadují pro svoji stabilizaci monovalentní ionty. (cs)
http://linked.open...tniCyklusProjektu	ZBKU
http://linked.open.../cep/klicoveSlovo	molecular dynamics two-dimensional condensation voltammetry DNA adsorption G-DNA electrochemical impedance spectroscopy electrode double layer mixed quartet nucleoside adsorption polypeptide adsorption quadruplex quanine quartet
is http://linked.open...vavai/riv/projekt of	Electrochemical Detection of Interactions of Echinomycin with DNA at Mercury Film Electrodes (MFE). Electrochemical impedance spectroscopy of single-stranded and double-helical polynucleotides Electrochemical detection of the interactions of chinoxaline and antracykline antibiotics with DNA Electrochemical impedance spectroscopy of polynucleotides. Electrochemical detection of interactions of echinomycin with DNA at mercury film electrodes (MFE). Electrochemical impedance spectroscopy of polynucleotides. Electrochemical impedance spectroscopy of single-stranded and double-helical polynucleotides. Two-dimensional condensation of nucleic acid components at mercury film and gold electrodes. On the adsorption kinetics of phase transients of adenosine at the different carbon electrodes modified with a mercury layer On the adsorption and kinetics of phase transients of adenosine at the different carbon electrodes modified with a mercury layer. Co je biofyzika ? Two-dimensional condensation of nucleic acid components at mercury film and gold electrodes Application of carbon electrodes modified with a mercury layer of a different thickness for studies of the adsorption and kinetics of phase transients of cytidine. On the formation kinetics of two-dimensional cytidine films. Structure and stability of cytidine adlayers na Au(111) , carbon electrodes with thin film of mercury (MFE) a Hg electrode. Structure and stability of cytidine adlayers at the Hg electrode and carbone electrode covered with a mercury film. Adsorption of polyvinylsulfate and polysodium 4-styrene sulfonate at the mercury electrode. Structural dynamics and cation interactions of DNA quadruplex molecules containing mixed guanine/cytosine quartets revealed by large-scale MD simulations Study of interactions of nucleic acids with modified electrodes surfaces by electrochemical impedance spectroscopy. Electrochemical impedance spectroscopy of polynucleotide adsorption. Electrochemical analysis of nucleic acids. volution of electrochemical methods - from virtual possibilities to virtual instruments. Electrochemical properties of surface active compounds. Electrochemical analysis of nucleic acids. Interaction of DNA with echinomycin at the mercury electrode surface as detected by impedance and chronopotentiometric measurements. Impedance analysis of DNA and DNA-drug interactions on thin mercury film electrodes. Impedance measurements of nucleic acids. Impedace Measurements of Nucleic Acids and Self - Assembled Lavers of Their Components Impedance measurements of nucleic acids and self-assembled layers of their components. Application of mercury thin film electrodes in electrochemical analysis Adsorptive Stripping Analysis of DNA with Admittance Detection Adsorption of nucleic acids, polynucleotides and nucleic acid components at mercury electrode. ADSORPTIVE STRIPPING ANALYSIS OF DAMAGE DNA WITH ADMITTANCE MEASUREMENTS Electrochemical impedance spectroscopy of single-stranded and double-helical polynucleotides Electrochemical impedance spectroscopy of native and denatured DNA. Nucleic acid sensing by impedance measurements Self-assembled layers of nucleic acid components at Hg and Au electrodes. Electroanalysis of biomacromolecules Adsorption of peptide nucleic acid and DNA decamers at electrically charged surfaces Measuremenmt of the membrane potential Thin film mercury electrodes in electrochemical analysis of the nucleic acids and their componends
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA4004002/2000/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA4004002/2001/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA4004002/2002/ico%3A68081707 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/IAA4004002/2003/ico%3A68081707

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