About: Adjuvant and immunotherapeutic properties of Bordetella pertussis adenylate cyclase toxin

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About: Adjuvant and immunotherapeutic properties of Bordetella pertussis adenylate cyclase toxin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GP310/09/P582
Description	Dendritic cells (DC) represent potent antigen presenting cells crucial in generation and regulation of immunity as well as tolerance, therefore it is of a particular interest to search for substances with adjuvant properties to instruct DC to modulate T cell-mediated immune responses. The adjuvant nature of cAMP signalling generated by cholera toxin is well documented. Here, we propose to investigate adjuvant activity of B. pertussis adenylate cyclase toxin (CyaA) to induce DC maturation and modulate the ability of DC to prime antigen specific CD4+ and CD8+ T cells in respect to their potential use in immunotherapy. Furthermore, the generation of antigen-induced T regulatory cells by CyaA-treated DC shall be examined together with their potential to prevent the onset of experimental autoimmune encephalomyelitis in mouse model. Also the possibility of expansion of CD4+CD25+Fox3p+ Treg by CyaA-treated DC will be tested. Ex vivo CyaA-treated DC might present an elegant strategy how to use adjuvant properties of CyaA-mediated cAMP signalling and bypass its possible toxic effects in vivo. (en) Cílem projektu je charakterizovat vliv působení adenylát-cyklázového toxinu na maturaci dendritických buněk a na jejich schopnost indukova specifické T buněčné odpovědi, včetně expanze T regulačních buněk s imunoterapeutickým potenciálem.
Title	Adjuvant and immunotherapeutic properties of Bordetella pertussis adenylate cyclase toxin (en) Adjuvantní a imunoterapeutické vlastnosti adenylát-cyklázového toxinu z Bordetella pertussis
skos:notation	GP310/09/P582
http://linked.open...avai/cep/aktivita	Post-graduate (doctorate) grants
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/GP310%2F09%2FP582/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/GP310%2F09%2FP582/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-03-02 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	91734125
http://linked.open...ai/cep/hlavniObor	EC - Imunologie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	dendritické buňky; CyaA; cAMP; adjuvans,T cells (en)
http://linked.open...ep/partnetrHlavni	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	6 (xsd:int)
http://linked.open...enychVysledkuVRIV	6 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-04-16 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/310%2F09%2FP582
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open.../vavai/cep/soutez	SGA02009GA1PD
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open...ep/zahajeniReseni	2009-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	The project was excellent, both in terms of expertise and in terms of disbursement of funds. (en) Řešení projektu proběhlo na vynikající úrovni, a to jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
http://linked.open...tniCyklusProjektu	ZBKU
http://linked.open.../cep/klicoveSlovo	CyaA adjuvans cAMP dendritické buňky
is http://linked.open...vavai/riv/projekt of	Bacteria and their Toxins Tamed for Immunotherapy In vitro activation of CMV-specific human CD8ţ T cells by adenylate RTX proteins: a highly diverse family secreted by a common mechanism Calcium Influx Rescues Adenylate Cyclase-Hemolysin from Rapid Cell Membrane Removal and Enables Phagocyte Permeabilization by Toxin Pores Bordetella Adenylate Cyclase Toxin Differentially Modulates Toll-Like Receptor-Stimulated Activation, Migration and T Cell Stimulatory Capacity of Dendritic Cells Heterosubtypic protection against influenza A induced by adenylate cyclase toxoids delivering conserved HA2 subunit of hemagglutinin
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GP310%2F09%2FP582/2009/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GP310%2F09%2FP582/2010/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GP310%2F09%2FP582/2011/ico%3A61388971 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/GP310%2F09%2FP582/2012/ico%3A61388971

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