About: Membrane interactions of proteins associated with alzheimer's disease and parkinson's disease implications for diseases' pathologies and therapeutic avenues     Goto   Sponge   NotDistinct   Permalink

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  • Cílem projektu bude charakterizovat interakci dvou amyloidogenních proteinů amyloidu-b (Ab) a a-synukleinu (a-syn) s modelovými membránami se zvláštním důrazem na vliv přítomnosti nanodomén (raftů) a oxidovaných fosfolipidů. Po charakterizaci na modelových systémech bude zkoumána míra interakce těchto proteinů s plasmatickými membránami živých buněk a bude porovnán mechanismus jejich působení a rozsah agregace na membránách. Nasbíraná data poté budou korelována s cytotoxicitou zmíněných amyloidogenních proteinů a případně budou navrženy inhibitory zabraňující interakci proteinů s membránou. (cs)
  • Aberrant misfolding and aggregation of amyloidogenic proteins is implicated in the progression of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and others. While the exact molecular factors responsible for the occurrence of these incurable diseases are still unknown, it has been found that peptides associated with these disorders bind and disrupt cellular membranes. However, thorough characterization of the impact of amyloid peptides upon the cell membrane and understanding the biological significance of such interactions are still incomplete. Therefore, this project aims to elucidate fundamental molecular details pertaining to membrane disruption by amyloidogenic peptides and their aggregates. This information might shed light on yet-unknown factors responsible for the devastating symptoms of seemingly unrelated neurodegenerative diseases. Attaining this understanding should particularly aid the search for possible therapeutic avenues for these diseases. (en)
Title
  • Membrane interactions of proteins associated with alzheimer's disease and parkinson's disease implications for diseases' pathologies and therapeutic avenues (en)
  • Membránová interakce proteinů spřažených s Alzheimerovou a Parkinsonovou chorobou: důsledky pro patogenezi těchto onemocnění a jejich léčbu (cs)
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  • membranes; beta-amyloid; alpha-synuclein; lipid rafts; polydiacetylene (en)
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