About: HDAC6 Inhibitor ACY-1215     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • HDAC6 Inhibitor ACY-1215
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • HDAC6 Inhibitor ACY-1215
NCI_META_CUI
  • CL429117
PDQ_Open_Trial_Search_ID
  • 698408
PDQ_Closed_Trial_Search_ID
  • 698408
FULL_SYN
  • HDAC6 Inhibitor ACY-1215PTNCI
  • Histone Deacetylase 6 InhibitorACY-1215SYNCI
  • ACY-1215CNNCI
DEFINITION
  • An orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY-1215 is able to reduce the toxic effects on normal, healthy cells.NCI
code
  • C96431
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