About: MTF-1 Inhibitor LOR-253 HCl     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • MTF-1 Inhibitor LOR-253 HCl
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • MTF-1 Inhibitor LOR-253 HCl
NCI_META_CUI
  • CL428185
PDQ_Open_Trial_Search_ID
  • 694483
PDQ_Closed_Trial_Search_ID
  • 694483
FULL_SYN
  • LOR-253 HClCNNCI
  • MTF-1 Inhibitor LOR-253 HClPTNCI
  • LT-253 HClCNNCI
DEFINITION
  • The hydrochloride salt of a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.NCI
code
  • C95724
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