About: Varlitinib Tosylate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Varlitinib Tosylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Varlitinib Tosylate
UMLS_CUI
  • C2987008
CAS_Registry
  • 1146629-86-8
FDA_UNII_Code
  • V4M8FWS152
Contributing_Source
  • FDA
Chemical_Formula
  • C22H19ClN6O2S.2C7H8O3S
FULL_SYN
  • 4,6-Quinazolinediamine, N(Sup 4)-(3-Chloro-4-(2-Thiazolylmethoxy)Phenyl)-N(Sup 6)-((4r)-4,5-Dihydro-4-Methyl-2-Oxazolyl)-, 4-Methylbenzenesulphonate (1:2)SNNCI
  • ARRY-543 DitosilateCNNCI
  • 4-N-(3-Chloro-4-(Thiazol-2-Ylmethoxy)Phenyl)-6-N-((4r)-4-Methyl-4,5-Dihydrooxazol-2- Yl)Quinazoline-4,6-Diamine Bis(4-Methylbenzenesulphonate)SNNCI
  • ARRY-543 DitosylateCNNCI
  • Varlitinib TosylatePTNCI
  • AR00334543 DitosilateCNNCI
  • AR00334543 DitosylateCNNCI
  • VARLITINIB TOSYLATEPTFDAV4M8FWS152
  • ARRY-334543 DitosylateCNNCI
DEFINITION
  • The tosylate salt form of varlitinib, an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone.NCI
code
  • C95226
is Has_Salt_Form of
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