About: Angiogenesis Inhibitor GT-111     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Angiogenesis Inhibitor GT-111
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Angiogenesis Inhibitor GT-111
NCI_META_CUI
  • CL378317
PDQ_Open_Trial_Search_ID
  • 580988
PDQ_Closed_Trial_Search_ID
  • 580988
Legacy_Concept_Name
  • GT-111
FULL_SYN
  • GT-111CNNCI
  • Angiogenesis Inhibitor GT-111PTNCI
DEFINITION
  • An adenovirus encoding an endothelial cell-specific, murine pre-proendothelin-1 (PPE-1) promoter and a Fas-based chimeric death receptor with potential anti-angiogenic activity. Endothelial cell-specific transcriptional control of the adenoviral vector is achieved by the use of a modified murine PPE-1 promoter that is specifically activated in PPE-1-expressing angiogenic endothelial cells residing in the tumor microvasculature. Subsequently, the Fas-c (Fas-chimeric) death receptor, containing Fas and tumor necrosis factor (TNF) receptor 1 (TNFR1) moieties, is expressed in angiogenic endothelial cells; endothelial cell-specific Fas-mediated apoptosis is initiated by the binding of TNF-alpha, abundant in the tumor microenvironment, to the TNFR1 moiety of the expressed Fas-c death receptor.NCI
code
  • C71539
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