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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pamidronic Acid
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pamidronic Acid
UMLS_CUI
  • C0043603
CAS_Registry
  • 40391-99-9
FDA_UNII_Code
  • OYY3447OMC
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat hypercalcemia (too much calcium in the blood) and cancer that has spread to the bones. It belongs to the family of drugs called bisphosphonates.NCI-GLOSS
Chemical_Formula
  • C3H11NO7P2
Legacy_Concept_Name
  • Pamidronic_Acid
FULL_SYN
  • PamidronateSYNCI
  • pamidronatePTNCI-GLOSSCDR0000045175
  • PAMIDRONIC ACIDPTFDAOYY3447OMC
  • Pamidronic AcidPTNCI
  • Pamidronic AcidPTDCP50681
DEFINITION
  • An amino- bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Pamidronic acid binds to and adsorbs onto hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated bone resorption, pamidronic acid decreases bone turnover rate, stabilizes the bone matrix and reduces hypercalcemia.NCI
code
  • C61875
sameAs
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