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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Terameprocol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Terameprocol
NSC_Code
  • 136955
UMLS_CUI
  • C0654036
CAS_Registry
  • 24150-24-1
FDA_UNII_Code
  • 53YET703F2
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It blocks proteins needed for cancer growth. It is a type of transcriptional inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 472205
PDQ_Closed_Trial_Search_ID
  • 472205
Chemical_Formula
  • C22H30O4
Legacy_Concept_Name
  • EM-1421
FULL_SYN
  • TERAMEPROCOLPTFDA53YET703F2
  • TerameprocolPTNCI
  • tetra-O-methyl NDGAPTNCI-GLOSSCDR0000556428
  • M4NABNCI
  • EM-1421PTNCI-GLOSSCDR0000556430
  • Tetramethoxynordihydroguaiaretic AcidSYNCI
  • tetra-O-methyl nordihydroguaiaretic acidPTNCI-GLOSSCDR0000532133
  • TMNDGAABNCI
  • 1,1'-(2,3-Dimethyl-1,4-butanediyl)bis(3,4-dimethoxybenzene)SNNCI
  • EM-1421CNNCI
  • Tetra-O-methyl-NDGASNNCI
  • Tetra-O-methyl Nordihydroguaiaretic AcidSNNCI
DEFINITION
  • A synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol competes with the transcription factor Sp1 for specific Sp1 DNA binding domains within gene promoter regions during DNA synthesis. In virally-infected cells, blocking of the Sp1 binding site suppresses Sp1-regulated viral promoter activity and gene expression, thereby inhibiting viral transcription and replication. In tumor cells, blockage of Sp1 binding sites by this agent interferes with the transcription of the Sp1-dependant genes cyclin-dependant kinase (Cdc2), survivin, and vascular endothelial growth factor (VEGF), which are overexpressed in a variety of cancers. By suppressing Sp1-regulated transcription of these genes, terameprocol may reduce tumor angiogenesis and tumor cell proliferation and induce tumor cell apoptosis.NCI
code
  • C61441
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