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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Dalfopristin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dalfopristin
UMLS_CUI
  • C0756085
CAS_Registry
  • 112362-50-2
FDA_UNII_Code
  • R9M4FJE48E
Contributing_Source
  • FDA
Chemical_Formula
  • C34H50N4O9S
Legacy_Concept_Name
  • Dalfopristin
FULL_SYN
  • DALFOPRISTINPTFDAR9M4FJE48E
  • Virginiamycin M1, 26-((2-(diethylamino)ethyl)sulfonyl)-26,27-dihydro-,(26R,27S)-SNNCI
  • DalfopristinPTNCI
  • RP 54476CNNCI
  • 3R,4R,5E,10E,12E,14S,26R,26aS)-26-((2-(Diethylamino)ethyl)sulfonyl)-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-3-isopropyl-4,12-dimethyl-3H-21,18-nitrilo-1H,22H-pyrrolo(2,1-c)(1,8,4,19)dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetroneSNNCI
DEFINITION
  • A semi-synthetic derivative of streptogramin A produced by streptomycetes. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome by binding to the 70S subunit, and also alters the configuration of the ribosome to make it more susceptible for streptogramin B binding. Dalfopristin is used in combination with quinopristin, a streptogramin B derivative. This combination is active against most gram-positive organisms, including Enterococcus faecium, and is also active against some gram-negative organisms and mycoplasma.NCI
code
  • C47468
sameAs
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