About: Thiethylperazine Maleate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Thiethylperazine Maleate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Thiethylperazine Maleate
NSC_Code
  • 130044
UMLS_CUI
  • C2350040
CAS_Registry
  • 1179-69-7
FDA_UNII_Code
  • RUK64CF26E
Contributing_Source
  • FDA
Chemical_Formula
  • C22H29N3S2.2C4H4O4
Legacy_Concept_Name
  • Thiethylperazine
CHEBI_ID
  • CHEBI:32216
FULL_SYN
  • Thiethylperazine MaleatePTNCI
  • 10H-Phenothiazine, 2-(ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioateSNNCI
  • GS-95CNNCI
  • THIETHYLPERAZINE MALEATEPTFDARUK64CF26E
  • TorecanBRNCI
  • NorzineBRNCI
DEFINITION
  • The maleate salt form of triethylperazine, a piperazine phenothiazine derivative and a dopamine antagonist used as antiemetic. Thiethylperazine blocks postsynaptic dopamine 2 (D2) receptors in the medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain. Peripherally, thiethylperazine blocks the vagus nerve in the gastrointestinal tract. In addition, this agent also shows antagonistic activities mediated through muscarinic receptors, H1-receptors, and alpha(1)-receptors.NCI
code
  • C29497
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
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