About: Valacyclovir     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Valacyclovir
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Valacyclovir
UMLS_CUI
  • C0249458
CAS_Registry
  • 124832-26-4
FDA_UNII_Code
  • MZ1IW7Q79D
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the prevention of fungal, bacterial, and viral infections in patients undergoing donor stem cell transplantation with cells that are infected with cytomegalovirus. It belongs to the family of drugs called antivirals.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 257236
PDQ_Closed_Trial_Search_ID
  • 257236
Chemical_Formula
  • C13H20N6O4
Legacy_Concept_Name
  • Valacyclovir
CHEBI_ID
  • CHEBI:35854
FULL_SYN
  • VALACYCLOVIRPTFDAMZ1IW7Q79D
  • ValacyclovirPTNCI
  • L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanineSNNCI
  • valacyclovirPTNCI-GLOSSCDR0000269430
  • ZelitrexBRNCI
DEFINITION
  • The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicella-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase.NCI
code
  • C28235
sameAs
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