About: Vorinostat

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Vorinostat
rdfs:subClassOf	Histone Deacetylase Inhibitor nodeID://b716170 nodeID://b716171 nodeID://b716172 nodeID://b716173 nodeID://b716174
Has_Target	Histone Deacetylases
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Vorinostat
NSC_Code	701852
UMLS_CUI	C0672708
CAS_Registry	149647-78-9
Accepted_Therapeutic_Use_For	Cutaneous T-cell Lymphoma
FDA_UNII_Code	58IFB293JI
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used to treat cutaneous T-cell lymphoma that does not get better, gets worse, or comes back during or after treatment with other drugs. It is also being studied in the treatment of other types of cancer. Vorinostat is a type of histone deacetylase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	37944
PDQ_Closed_Trial_Search_ID	37944
Chemical_Formula	C14H20N2O3
Legacy_Concept_Name	Suberoylanilide_Hydroxamic_Acid
FULL_SYN	N-Hydroxy-N'-phenyloctanediamideSNNCI VorinostatPTNCI vorinostatPTNCI-GLOSSCDR0000455153 SAHAPTNCI-GLOSSCDR0000455152 suberoylanilide hydroxamic acidSYNCI-GLOSSCDR0000044908 Suberanilohydroxamic AcidSYDCP09559 Suberanilohydroxamic AcidCNNCI SAHAABNCI ZolinzaPTNCI-GLOSSCDR0000514187 ZolinzaBRNCI VORINOSTATPTFDA58IFB293JI Suberoylanilide Hydroxamic AcidCNNCI L-001079038CNNCI
DEFINITION	A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic domain of the histone deacetylases (HDACs). This allows the hydroxamic moiety to chelate zinc ion located in the catalytic pockets of HDAC, thereby inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Hyperacetylation of histone proteins results in the upregulation of the cyclin-dependant kinase p21, followed by G1 arrest. Hyperacetylation of non-histone proteins such as tumor suppressor p53, alpha tubulin, and heat-shock protein 90 produces additional anti-proliferative effects. This agent also induces apoptosis and sensitizes tumor cells to cell death processes. Vorinostat crosses the blood-brain barrier.NCI
code	C1796
sameAs	VORINOSTAT VORINOSTAT
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0288128
is sameAs of	VORINOSTAT VORINOSTAT VORINOSTAT

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