About: Spiromustine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Spiromustine
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Spiromustine
NSC_Code
  • 172112
UMLS_CUI
  • C0075019
CAS_Registry
  • 56605-16-4
In_Clinical_Trial_For
  • Brain Tumors.
PDQ_Open_Trial_Search_ID
  • 39441
PDQ_Closed_Trial_Search_ID
  • 39441
Legacy_Concept_Name
  • Spiromustine
FULL_SYN
  • Spirohydantoin MustardSYNCI
  • SpiromustinePTNCI
  • SHMABNCI
  • Spirohydantoin mustardSYDTPNSC0172112
  • 1,3-diazaspiro(4,5)decane-2,4-dione,3-(2-(bis-chloroethyl)amino)ethylSNNCI
DEFINITION
  • A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)NCI
code
  • C1233
http://linked.open...y/mesh/hasConcept
Faceted Search & Find service v1.16.121 as of Mar 31 2025


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 14 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software