About: Proteasome Inhibitor MLN9708     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Proteasome Inhibitor MLN9708
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Proteasome Inhibitor MLN9708
UMLS_CUI
  • C2830202
CAS_Registry
  • 1201902-80-8
FDA_UNII_Code
  • E8R04MBQ04
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 635527
PDQ_Closed_Trial_Search_ID
  • 635527
Chemical_Formula
  • C20H23BCl2N2O9
Legacy_Concept_Name
  • Proteasome_Inhibitor_MLN9708
FULL_SYN
  • MLN9708PTFDAE8R04MBQ04
  • Proteasome Inhibitor MLN9708PTNCI
  • 1,3,2-dioxaborinane-4-acetic acid, 4-carboxy-2-((1r)-1-((2-((2,5-dichlorobenzoyl)amino)acetyl)amino)-3-methylbutyl)-6-oxo-SNNCI
  • MLN9708CNNCI
  • MLN-9708CNNCI
DEFINITION
  • An orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. Proteasome inhibitor MLN9708 inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated.NCI
code
  • C82653
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