About: 1-Methyl-d-Tryptophan     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • 1-Methyl-d-Tryptophan
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • 1-Methyl-d-Tryptophan
NCI_META_CUI
  • CL378076
ALT_DEFINITION
  • A substance being studied in the treatment of melanoma and many other types of cancer. 1-methyl-d-tryptophan blocks the breakdown of the amino acid tryptophan, which is needed for T cells (a type of immune system cell) to kill tumor cells. Giving 1-methyl-d-tryptophan to patients who have received chemotherapy for cancer may help kill more tumor cells. It is a type of enzyme inhibitor and immunosuppressant.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 579646
PDQ_Closed_Trial_Search_ID
  • 579646
Legacy_Concept_Name
  • _1-Methyl-d-Tryptophan
FULL_SYN
  • D-1MTPTNCI-GLOSSCDR0000599989
  • 1-MTABNCI
  • 1-methyl-d-tryptophanPTNCI-GLOSSCDR0000599960
  • 1-Methyl-d-TryptophanPTNCI
DEFINITION
  • A methylated tryptophan with anti-immunosuppressive activity. 1-methyl-d-tryptophan inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.NCI
code
  • C71535
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