About: Aerosolized Liposomal Rubitecan     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Aerosolized Liposomal Rubitecan
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Aerosolized Liposomal Rubitecan
UMLS_CUI
  • C1831773
PDQ_Open_Trial_Search_ID
  • 473242
PDQ_Closed_Trial_Search_ID
  • 473242
Legacy_Concept_Name
  • Aerosolized_Liposomal_9-Nitrocamptothecin
FULL_SYN
  • Aerosolized liposomal 9-nitro-20(S)-camptothecinSYNCI
  • Aerosolized Liposomal RubitecanPTNCI
DEFINITION
  • An aerosolized liposomal preparation of rubitecan, a water-insoluble derivative of camptothecin with potential antineoplastic activity. Rubitecan (or 9-nitro-20 (S)-camptothecin) and its active metabolite 9-aminocamptothecin (9-AC) selectively stabilize topoisomerase I-DNA covalent complexes during S-phase, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. This agent is formulated with dilauroylphosphatidylcholine and nebulized in particle sizes of 1.2-1.6 micrometer mass median aerodynamic diameter.NCI
code
  • C61071
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