About: CNGRC Peptide-TNF Alpha Conjugate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CNGRC Peptide-TNF Alpha Conjugate
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • CNGRC Peptide-TNF Alpha Conjugate
UMLS_CUI
  • C1143119
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is made by linking tumor necrosis factor (TNF) to a peptide. The peptide binds to tumor blood vessels, and TNF damages them. It is a type of biological response modifier.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 403156
PDQ_Closed_Trial_Search_ID
  • 403156
Legacy_Concept_Name
  • CNGRC_Peptide-Tumor_Necrosis_Factor_Alpha_Conjugate
FULL_SYN
  • CNGRC Peptide-TNF Alpha ConjugatePTNCI
  • CNGRC Peptide-TNF Alpha ConjugateSYNCI
  • NGR-TNFPTNCI-GLOSSCDR0000413951
  • NGR-hTNFABNCI
  • tumor vasculature-targeted tumor necrosis factor alphaPTNCI-GLOSSCDR0000428262
DEFINITION
  • A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis. (NCI05)NCI
code
  • C48383
http://linked.open...y/mesh/hasConcept
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