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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Riluzole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Riluzole
UMLS_CUI
  • C0073379
CAS_Registry
  • 1744-22-5
FDA_UNII_Code
  • 7LJ087RS6F
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat a nerve disease called amyotrophic lateral sclerosis (ALS). It is also being studied in the treatment of melanoma (a type of skin cancer). Riluzole blocks the release of a substance that melanoma cells need to grow. It is a type of glutamate release inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 594943
PDQ_Closed_Trial_Search_ID
  • 594943
Chemical_Formula
  • C8H5F3N2OS
Legacy_Concept_Name
  • Riluzole
FULL_SYN
  • RILUZOLEPTFDA7LJ087RS6F
  • RilutekPTNCI-GLOSSCDR0000631057
  • RilutekBRNCI
  • RiluzolePTNCI
  • riluzolePTNCI-GLOSSCDR0000631054
  • 2-Amino-6-(trifluoromethoxy)benzothiazoleSNNCI
DEFINITION
  • A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is unknown, its pharmacological activities in motor neurons include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors. In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission.NCI
code
  • C47704
sameAs
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