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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Valproic Acid
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Valproic Acid
NSC_Code
  • 93819
UMLS_CUI
  • C0042291
CAS_Registry
  • 99-66-1
Accepted_Therapeutic_Use_For
  • Epilepsy; Mania; Migraine
In_Clinical_Trial_For
  • Kaposis sarcoma; leukemia; myelodysplastic syndrome
FDA_UNII_Code
  • 614OI1Z5WI
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat epileptic seizures and bipolar disorder and to prevent migraine headaches. It is also being studied in the treatment of several types of cancer. It blocks an enzyme that cells need to grow and may cause cancer cells to die. It also blocks the growth of new blood vessels that tumors need to grow. It is a type of anticonvulsant, histone deacetylase (HDAC) inhibitor, antimaniacal, migraine headache prophylactic, and antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 350047
PDQ_Closed_Trial_Search_ID
  • 350047
Chemical_Formula
  • C8H16O2
Legacy_Concept_Name
  • Valproic_Acid
CHEBI_ID
  • CHEBI:39867
FULL_SYN
  • Di-n-propylacetic AcidSNNCI
  • 2-Propylpentanoic AcidSNNCI
  • VALPROIC ACIDPTFDA614OI1Z5WI
  • Valproic AcidPTNCI
  • valproic acidPTNCI-GLOSSCDR0000367423
  • Valproic AcidPTDCP50563
  • StavzorPTNCI-GLOSSCDR0000662027
  • DepakenePTNCI-GLOSSCDR0000662026
  • DepakeneBRNCI
  • 2-Propylvaleric AcidSNNCI
  • ValproateSYNCI
DEFINITION
  • A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)NCI
code
  • C29536
sameAs
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
is Has_Free_Acid_Or_Base_Form of
is sameAs of
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