About: Recombinant Interleukin-12

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Recombinant Interleukin-12 Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Recombinant Interleukin-12
equivalentClass	nodeID://b640573
Has_Target	Receptors, Interleukin-12
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Recombinant Interleukin-12
NSC_Code	672423
UMLS_CUI	C1524115
CAS_Registry	187348-17-0
In_Clinical_Trial_For	AIDS-related lymphoma; Colorectal cancer; Kidney cancer; Lung carcinoma; Melanoma; Mycosis fungoides; Neuroblastoma; Non Hodgkins lymphoma; Ovarian epithelial cancer; Peritoneal cavity cancer; Renal cell cancer; Sarcomas; Unspecified solid tumors
ALT_DEFINITION	One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-12 is made mainly by B lymphocytes and macrophages. It causes other immune cells to make cytokines and increases the growth of T lymphocytes. It may also block the growth of new blood vessels. Interleukin-12 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-12 is a type of cytokine.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42153
PDQ_Closed_Trial_Search_ID	42153
Legacy_Concept_Name	Therapeutic_Interleukin-12
FULL_SYN	Natural Killer Cell Stimulatory FactorSYNCI Cytotoxic Lymphocyte Maturation FactorSYNCI IL-12PTNCI-GLOSSCDR0000044418 Interleukin-12SYDTPNSC0672423 Recombinant Interleukin-12PTNCI IL-12ABNCI interleukin-12PTNCI-GLOSSCDR0000045426 Recombinant human interleukin-12 (IL-12) cytokineSYNCI Interleukin 12PTDCP09122 Ro 24-7472CNNCI
DEFINITION	A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Recombinant interleukin-12 binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. (NCI04)NCI
code	C1380
is someValuesFrom of	nodeID://b645165 nodeID://b647718 nodeID://b647725 nodeID://b667349 nodeID://b682373 nodeID://b682374 nodeID://b682379 nodeID://b683114 nodeID://b683542 nodeID://b683545 nodeID://b683550 nodeID://b683551 nodeID://b683553 nodeID://b683555 nodeID://b683559 nodeID://b683728 nodeID://b725917 nodeID://b725922 nodeID://b725926 nodeID://b725975 nodeID://b725981 nodeID://b725983

Faceted Search & Find service v1.16.121 as of Mar 31 2025

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 40 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software