About: Cimetidine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz:8890 associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B60BF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B60C0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B60C1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B60C2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B60C3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B60C4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B60C5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B60C6-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Michnovicz JJ, Galbraith RA: Cimetidine inhibits catechol estrogen metabolism in women. Metabolism. 1991 Feb;40(2):170-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1988774 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	2 hours (en)
http://linked.open...ugbank/indication	For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion. (en)
http://linked.open...bank/manufacturer	Cardinal Health Carlisle Laboratories Inc. Chattem Chemicals Inc. Concord Labs Consolidated Midland Corp. Contract Pharm CVS Pharmacy Darby Dental Supply Co. Inc. Dept Health Central Pharmacy Actavis mid atlantic llc DispenseXpress Inc. Dispensing Solutions Diversified Healthcare Services Inc. Eon Labs Equaline Vitamins Eisai Inc. A-S Medication Solutions LLC Pfizer Inc. Auriga Pharmaceuticals LLC Barr Pharmaceuticals Baxter International Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Bioniche Pharma Bryant Ranch Prepack C.O. Truxton Inc.
sameAs	Cimetidine Cimetidine
Title	Cimetidine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/bindingdb/22889 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/chebi/3699 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/chemspider/2654 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/drugbank/DB00501 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/guide-to-pharmacology/1231 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/iuphar/1231 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/kegg-drug/D00295 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/national-drug-code-directory/0093-8181-01 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/pharmgkb/PA449001 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/pubchem-compound/2756 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/pubchem-substance/46505360 http://linked.opendata.cz/resource/drugbank/drug/DB00501/identifier/wikipedia/Cimetidine
http://linked.open...mechanismOfAction	Cimetidine binds to an H<sub>2</sub>-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity. (en)
http://linked.open...drugbank/packager	Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Amerisource Health Services Corp. Sandoz A-S Medication Solutions LLC A-S Medication Solutions LLC Baxter International Inc. Bristol-Myers Squibb Co. Bryant Ranch Prepack Cardinal Health Central Texas Community Health Centers Bayer healthcare pharmaceuticals inc Actavis Group Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Apotex Inc. Apotheca Inc. A-S Medication Solutions LLC Bryant Ranch Prepack Cardinal Health Carlsbad Technology Inc. Comprehensive Consultant Services Inc. Bristol myers squibb co Dispensing Solutions Diversified Healthcare Services Inc. Barr laboratories inc Heartland Repack Services LLC International Laboratories Inc. Ivax Pharmaceuticals Pharmaceutical Utilization Management Program VA Inc. Lake Erie Medical and Surgical Supply Lupin Pharmaceuticals Inc. Graceway pharmaceuticals llc Jhp pharmaceuticals llc Medvantx Inc. Merck & Co. Murfreesboro Pharmaceutical Nursing Supply Monarch pharmaceuticals inc Mylan Neuman Distributors Inc. Nucare Pharmaceuticals Inc. Palmetto Pharmaceuticals Inc. PCA LLC PD-Rx Pharmaceuticals Inc. Pharmaceutical Utilization Management Program VA Inc.

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