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| Description
| - Současné znalosti o patogenezi kondylomat, prekanceróz a karcinomů vulvy vedly k změně klasifikace prekanceróz. Projekt si klade za cíle vytvořit diagnosticko – terapeutické algoritmy pro jednotlivé jednotky, rozšířit znalosti o prediktivních faktorech. Projekt plánuje korelovat HPV profily lézí s histologickou charakteristikou, s důrazem na rozlišení morfologických znaků HPV pozitivních a HPV negativních. HPV profily budou korelovány s expresí imunohistochemických markerů, především pl6INK4a (p16). Dále bude vyhodnocen diagnostický přínos protilátek proti minichromosome maintenance protein 2 (MCM2), DNA topoisomeráze II alfa (TOP IIA), cyclinu E a ProExC (směs protilátek proti MCM2 a TOP IIA). Cílem je dosáhnout zvýšení specificity a senzitivity histopatologického vyšetření a tím nově optimalizovat diagnosticko–terapeutické algoritmy. (cs)
- Current knowledge about pathogenesis of vulvar lesions including genital warts, precancerous lesions, vulvar cancer has led to an update of classification of precancerous lesions. The aim is to find optimal algorithms for each entity and to enhance our knowledge on predictive factors which can be used for clinical praxis. In this project we plan to correlate HPV profiles of lesions with histopathological characteristics especially morphological diagnostic sings of HPV positive and HPV negative lesions. HPV profiles will be correlated with expression of immunohistochemical markers, mainly p161NK4a(p16). Another predictive factors will be assessed including minichromosome maintenance protein 2 (MCM2), DNA topoisomerase II Alfa (TOP IIA), cycline E and ProExC (mixture of antibodies against MCM2 and TOP IIA). When combined the predictive factors could improve sensitivity and specificity of histopathological examination. Diagnostic and therapeutic algorithms should be clinical outcome of the project. (en)
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| Title
| - Genital warts, premalignant lesions and vulvar carcinoma diagnostic and therapeutical management optimalisation. (en)
- Optimalizace diagnosticko-terapeutického managementu kondylomat, prekanceróz a karcinomů vulvy. (cs)
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| http://linked.open...vai/cislo-smlouvy
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| http://linked.open...avai/druh-souteze
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| http://linked.open...domain/vavai/faze
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| http://linked.open...vavai/hlavni-obor
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| http://linked.open...vavai/id-aktivity
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| http://linked.open.../vavai/id-souteze
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| http://linked.open...n/vavai/kategorie
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| http://linked.open...vai/klicova-slova
| - vulva; condylomata; precancerous leasions; HPV profile; pl6INK4a; diagnosis; prognosis; therapy (en)
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| http://linked.open...avai/konec-reseni
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| http://linked.open...nujicich-prijemcu
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| http://linked.open...avai/poskytovatel
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| http://linked.open...avai/start-reseni
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| http://linked.open...ai/statni-podpora
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| http://linked.open...vavai/typProjektu
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| http://linked.open...ai/uznane-naklady
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| http://linked.open...ai/pocet-prijemcu
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| http://linked.open...cet-spoluprijemcu
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| http://linked.open...ai/pocet-vysledku
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| http://linked.open...ku-zverejnovanych
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| is http://linked.open...ain/vavai/projekt
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