About: Local pharmacological inhibition of neointimal proliferation in venous grafts after interposing them into the abdominal aorta in rats     Goto   Sponge   NotDistinct   Permalink

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  • Podstatou výzkumného projektu je zavedení techniky zevního resorbovatelného obalu autotranplantované cévy , který by obsahoval a uvolňoval antiproliferativní látky . Použítím modelu na kryse plánujeme přechod do preklinické a klinické praxe vytvořením nové metody k léčení tzv. vein graft dissease u žilních autologních či allogenních graftů. (cs)
  • "The expected outcome of our project is the introduction of a novel technique for a periadventitial polymer-based resorbable system for sustained release of antiproliferative drugs, enveloped around the auto-transplanted vein. We plan to use rats as a suitable model for developing this advanced technique and for its future introduction into pre-clinical and clinical practice to prevent and treat so-called ""vein graft disease"" occurring in autologous or allogenic vein grafts" (en)
Title
  • Lokální medikamentozní inhibice neointimální proliferace žilních graftů po interpozici do abdominální aorty u potkana (cs)
  • Local pharmacological inhibition of neointimal proliferation in venous grafts after interposing them into the abdominal aorta in rats (en)
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  • neointimal hyperplasia; inhibition of proliferation; autotransplantation; external resorbable envelope; sirolimus; vein graft remodelation; vein graft aorto-aortic bypass; vein graft dissease (en)
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