About: Evaluation of possibility of medical use of Inerleukin 6 and Tumor necrosis factor alfa for acceleration of hypetrophy of liver parenchyma - animal model simulating conditions at patients after embolization of the right branch of portal vein     Goto   Sponge   NotDistinct   Permalink

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  • On animal model we will ligate right sided branch of portal vein. Contemporary we will implant portal catheter. Through this way we will aplicate single dose of IL-6 or TNF-a or physiological solution. In the postoperative period we will meassure by ultrasonography the hypertrophy of right liver lobe and atrophy of left lobe. The proliferative activity of hepatocytes will be compared by serum level of TGF-a and HGF in peripheral blood. After finish of this experiment and after killing of animals we will verify histologically mitotic activity of liver parenchyma. The aim of this experiment is to form the animal model of the embolization of portal vein in human medicine and to demonstrate the influence of IL-6 and TNF-a upon the hypertrophy of liver parenchyma. (en)
  • Na zvířecím modelu bude proveden podvaz pravostranné portální žíly. Současně bude zaveden portální katetr. Touto cestou bude po 24 hodinách jednorázově aplikován IL-6 nebo TNF-alfa či fyziologický roztok. V pooperačním období bude ultrasonograficky sledována hypetrofie levého a atrofie pravého laloku.Proliferační aktivita hepatocytů bude porovnávána pomocí sérové hladiny TGF-alfa a HGF v periferní krvi. Monitora klinického stavu zvířete. Po skončení experimentu a usmrcení modelu bude histologicky ověřena mitotická aktivita jaterního parenchymu. Vytvořit zvířecí model embolizace portální žíly v humánní medicíně. Dokázat vliv IL-6 a TNF-alfa na hypertrofii jaterního parenchymu. (cs)
Title
  • Posouzení možnosti léčebného použití interleukinu 6 a tumor necrosis factor alfa k akceleraci hypertrofie jaterního parenchymu - zvířecí model simulující stav u pacientů po embolizaci větce portální žíly (cs)
  • Evaluation of possibility of medical use of Inerleukin 6 and Tumor necrosis factor alfa for acceleration of hypetrophy of liver parenchyma - animal model simulating conditions at patients after embolization of the right branch of portal vein (en)
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  • liver hypertrophy; embolization of portal vein; Interleukin 6; Tumor necrosis factor alfa; Tumor growth factor; Hepatal growth factor (en)
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