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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz:8890 associated with source document(s)

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Description
  • The principal aim of this project is to accelerate the early stages of the drug discovery process, in particular identification of novel compounds possessing relevant pharmacological properties. In order to achieve our goal, the project combines (i) development of synthetic routes to access novel biologically active compounds, (ii) application of combinatorial chemistry methods to provide access to large number of their derivatives, (iii) and biological testing in vitro. Close collaboration between institutions with proven record in their respective research areas will reduce the time needed for discovery of promising biologically active compounds and, in the most ambitious scenario, lead to discovery of a new drug. The subject of this research proposal is to expand the existing collaboration in the area of drug discovery, particularly in the search for new heterocyclic compounds possessing pharmacologically relevant properties, between Department of Organic Chemistry, Palacky University, Olomouc, a (en)
  • Základním cílem projektu je zefektivnění výzkumu nových biologicky aktivních látek. Poznatky dosažené řešením projektu budou zahrnovat výsledky výzkumu metodiky přípravy těchto látek a výsledky jejich protinádorové aktivity a působení na buněčný cyklus.
Title
  • Research of new organic compounds with anticancer activity with use of combinatorial chemistry (en)
  • Výzkum nových sloučenin s protinádorovou aktivitou za pomoci kombinatoriální chemie
skos:notation
  • ME09057
http://linked.open...avai/cep/aktivita
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  • synthesis; solid phase synthesis; combinatorial chemistry; anticancer activity; enzyme inhibition (en)
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  • In 2012 the research was focused on preparation of chemical libraries of biologically active compounds and on advanced testing of biological activity. (en)
  • V roce 2012 byla pozornost věnována přípravě dalších chemických knihoven biologicky aktivních sloučenin a dále pokročilému testování biologické aktivity. (cs)
http://linked.open...tniCyklusProjektu
http://linked.open.../cep/klicoveSlovo
  • synthesis
  • anticancer activity
  • combinatorial chemistry
  • solid phase synthesis
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