About: New Mouse Models for Studies on Biomedical Complex Traits and Human Diseases and for Systems Genetics     Goto   Sponge   NotDistinct   Permalink

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Description
  • The project is aimed at introduction of intersubspecific chromosome substitution strains as model organanisms for studies of heredity of gene expression levels in various tissues and organs at physiological and pathological states. Special attention is paid to analysis of genes responsible for male sterility. The use of the chromosome substitution strains will be realized in collaboration with the european laboratories ingaged in SYSGENET – COST project, whose main aim is to integrate genetic resources from individual laboratories into European genetic reference populations (GRP). (en)
  • Cílem projektu je využití souboru chromozomálních substitučních kmenů jako modelových organismů pro studium dědičnosti exprese genů v různých tkáních v normálních a pathologických stavech, se zvláštním zaměřením na studium genů kontrolujících samčí neplodnost. Tento cíl pak realizovat ve spolupráci s evropskými pracovišti v rámci projektu SYSGENET a zajistit tak jeho integraci v rámci evropských genetických referenčních populací.
Title
  • New Mouse Models for Studies on Biomedical Complex Traits and Human Diseases and for Systems Genetics (en)
  • Nové myší modely pro studium biomedicínských komplexních znaků a lidských chorob a pro systémovou genetiku
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  • LD11079
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  • Model organisms for himan diseases. Genetic reference populations. Chromosome substitution strains. Genetics of gene expression. Genetics of male sterility. (en)
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  • Projekt umožnil participaci laboratoře v programu European Cooperation in Science and Technology (COST) SYSGENET, zaměřeném na komplexní genové interakce na modelu myších referenčních populací. Pražská laboratoř přispěla panelem chromozomálních (cs)
  • Project enabled involvement of the laboratory in the program of European Cooperation in Science and Technology (COST) SYSGENET, focused on complex gene interactions using as a model mouse reference populations. The Prague laboratory contributed with a panel of chromosome substitution strains. (en)
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